Scientific publication : GP ASIT + TM

Mode of action

Immunologic Mechanisms of Short-course of Lolium Perenne Peptide Immunotherapy: 
A Randomized Double-Blind Placebo-Controlled Trial

Hanisah Sharif,  Iesha Singh, Lubna Kouser, Ralph Mösges, Marie-Alix Bonny, Angeliki Karamani, Rebecca V. Parkin, Nicolas Bovy, Uday Kishore, Abigail Robb, Michael Katotomichelakis, Gabriele

Holtappels, Lara Derycke, Francis Corazza, Rémy von Frenckell, Nathalie Wathelet, Jean Duchateau, Thierry Legon, Sabine Pirotton, Stephen R. Durham, Claus Bachert, Mohamed H. Shamji

J Allergy Clin Immunol, Sept 2019, Vol 144, p738-749

Phase III study (BTT009)

Short-course of grass allergen peptides immunotherapy over three weeks reduces seasonal symptoms in allergic rhinoconjunctivitis with/without Asthma: A randomized, multicenter, double-blind, placebo-controlled trial

Ralph Mösges, Claus Bachert, Petr Panzner, Moises A. Calderon, Ludo Haazen, Sabine Pirotton, Nathalie Wathelet, Stephen R Durham, Marie-Alix Bonny, Thierry Legon, Remy von Frenckell, Oliver Pfaar and Mohamed H Shamji

Allergy, 2018; DOI: 10.1111/all.13433

Phase IIB study (BTT008)

A randomized, double-blind, placebo-controlled, dose-finding trial with Lolium perenne peptide immunotherapy

  1. Mösges, E. M. Kasche, E. Raskopf, J. Singh, L. Sohlich, A. Astvatsatourov, K. Shah-Hosseini, S. Pirotton, L. Haazen, S. R. Durham, T. Legon, G. Zadoyan and M. H. Shamji

Allergy,2017; DOI: 10.1111/all.13358

Phase IIa study (BTT007)

Lolium perenne peptide immunotherapy is well tolerated and elicits a protective B-cell response in seasonal allergic rhinitis patients

  1. Mösges, A. F. Koch, E. Raskopf, J. Singh, K. Shah-Hosseini, A. Astvatsatourov, B. Hauswald, Y. Yarin, F. Corazza, L. Haazen, S. Pirotton, S. Allekotte, G. Zadoyan, T. Legon, S. R. Durham and M. H. Shamji

Allergy 2018 ; DOI: 10.1111/all.13392

Phase I study (BTT004)

Lolium perenne peptides for treatment of grass pollen allergy: A randomized, double-blind, placebo-controlled clinical trial

M.H. Shamji, J. Ceuppens, C. Bachert, P. Hellings, G. Placier, G. Thirion, N. Bovy, S.R. Durham, J. Duchateau, T. Legon, S. Pirotton

J Allergy Clin Immunol 2018 Vol 141, Issue 1, p448-451